Duration of RT-PCR positivity in severe acute respiratory syndrome.
Identifieur interne : 004858 ( Main/Exploration ); précédent : 004857; suivant : 004859Duration of RT-PCR positivity in severe acute respiratory syndrome.
Auteurs : C M Chu [République populaire de Chine] ; W S Leung ; V C C. Cheng ; K H Chan ; A W N. Lin ; V L Chan ; J Y M. Lam ; K S Chan ; K Y YuenSource :
- The European respiratory journal [ 0903-1936 ] ; 2005.
Descripteurs français
- KwdFr :
- ADN viral (analyse), Adolescent, Adulte, Adulte d'âge moyen, Charge virale, Facteurs temps, Femelle, Humains, Indice de gravité médicale, Intervalles de confiance, Mâle, Probabilité, Pronostic, RT-PCR, Sensibilité et spécificité, Syndrome respiratoire aigu sévère (diagnostic), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (isolement et purification), Études de cohortes, Études rétrospectives, Évaluation des risques.
- MESH :
- analyse : ADN viral.
- diagnostic : Syndrome respiratoire aigu sévère.
- isolement et purification : Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- Adolescent, Adulte, Adulte d'âge moyen, Charge virale, Facteurs temps, Femelle, Humains, Indice de gravité médicale, Intervalles de confiance, Mâle, Probabilité, Pronostic, RT-PCR, Sensibilité et spécificité, Études de cohortes, Études rétrospectives, Évaluation des risques.
English descriptors
- KwdEn :
- Adolescent, Adult, Cohort Studies, Confidence Intervals, DNA, Viral (analysis), Female, Humans, Male, Middle Aged, Probability, Prognosis, Retrospective Studies, Reverse Transcriptase Polymerase Chain Reaction, Risk Assessment, SARS Virus (isolation & purification), Sensitivity and Specificity, Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (virology), Severity of Illness Index, Time Factors, Viral Load.
- MESH :
- chemical , analysis : DNA, Viral.
- diagnosis : Severe Acute Respiratory Syndrome.
- isolation & purification : SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Adolescent, Adult, Cohort Studies, Confidence Intervals, Female, Humans, Male, Middle Aged, Probability, Prognosis, Retrospective Studies, Reverse Transcriptase Polymerase Chain Reaction, Risk Assessment, Sensitivity and Specificity, Severity of Illness Index, Time Factors, Viral Load.
Abstract
Severe acute respiratory syndrome (SARS) is a highly infectious respiratory infection with a high mortality. The duration of infectivity is unknown. The RT-PCR positivity for SARS-associated coronavirus (SARS-CoV) was followed in 45 virologically confirmed SARS patients. Serial RT-PCRs for SARS-CoV were performed in the nasopharyngeal aspirate, stool and urine of 45 SARS patients who survived until discharge. All patients had at least one site that was positive for SARS-CoV on presentation. Time to RT-PCR conversion was studied in all patients. There were 15 males (33.3%) and 30 females (66.7%), with a mean+/- SD age of 40.7+/-14.7 yrs. The median (range) time of RT-PCR conversion was 30 days (2-81). On discharge from the hospital, 18 (40%) remained RT-PCR positive in at least one site. For patients with positive RT-PCR on discharge, the median (range) time to RT-PCR conversion after discharge was 13 days (2-60). A significant proportion of severe acute respiratory syndrome patients remained RT-PCR positive for severe acute respiratory syndrome-associated coronavirus for a substantial duration after discharge. The clinical significance is unknown and this finding merits further study. It is prudent to advise patients to adhere to strict personal hygiene on discharge until RT-PCR becomes negative.
DOI: 10.1183/09031936.04.00057804
PubMed: 15640317
Affiliations:
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Le document en format XML
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Cheng</name></author><author><name sortKey="Chan, K H" sort="Chan, K H" uniqKey="Chan K" first="K H" last="Chan">K H Chan</name></author><author><name sortKey="Lin, A W N" sort="Lin, A W N" uniqKey="Lin A" first="A W N" last="Lin">A W N. Lin</name></author><author><name sortKey="Chan, V L" sort="Chan, V L" uniqKey="Chan V" first="V L" last="Chan">V L Chan</name></author><author><name sortKey="Lam, J Y M" sort="Lam, J Y M" uniqKey="Lam J" first="J Y M" last="Lam">J Y M. Lam</name></author><author><name sortKey="Chan, K S" sort="Chan, K S" uniqKey="Chan K" first="K S" last="Chan">K S Chan</name></author><author><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K Y" last="Yuen">K Y Yuen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:15640317</idno><idno type="pmid">15640317</idno><idno type="doi">10.1183/09031936.04.00057804</idno><idno type="wicri:Area/PubMed/Corpus">002958</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002958</idno><idno type="wicri:Area/PubMed/Curation">002958</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002958</idno><idno type="wicri:Area/PubMed/Checkpoint">002739</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002739</idno><idno type="wicri:Area/Ncbi/Merge">000D07</idno><idno type="wicri:Area/Ncbi/Curation">000D07</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D07</idno><idno type="wicri:doubleKey">0903-1936:2005:Chu C:duration:of:rt</idno><idno type="wicri:Area/Main/Merge">004B60</idno><idno type="wicri:Area/Main/Curation">004858</idno><idno type="wicri:Area/Main/Exploration">004858</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Duration of RT-PCR positivity in severe acute respiratory syndrome.</title><author><name sortKey="Chu, C M" sort="Chu, C M" uniqKey="Chu C" first="C M" last="Chu">C M Chu</name><affiliation wicri:level="1"><nlm:affiliation>Division of Respiratory Medicine, Dept of Medicine and Geriatrics, United Christian Hospital, Hong Kong SAR, China. chucm@ha.org.hk</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Division of Respiratory Medicine, Dept of Medicine and Geriatrics, United Christian Hospital, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Leung, W S" sort="Leung, W S" uniqKey="Leung W" first="W S" last="Leung">W S Leung</name></author><author><name sortKey="Cheng, V C C" sort="Cheng, V C C" uniqKey="Cheng V" first="V C C" last="Cheng">V C C. Cheng</name></author><author><name sortKey="Chan, K H" sort="Chan, K H" uniqKey="Chan K" first="K H" last="Chan">K H Chan</name></author><author><name sortKey="Lin, A W N" sort="Lin, A W N" uniqKey="Lin A" first="A W N" last="Lin">A W N. Lin</name></author><author><name sortKey="Chan, V L" sort="Chan, V L" uniqKey="Chan V" first="V L" last="Chan">V L Chan</name></author><author><name sortKey="Lam, J Y M" sort="Lam, J Y M" uniqKey="Lam J" first="J Y M" last="Lam">J Y M. Lam</name></author><author><name sortKey="Chan, K S" sort="Chan, K S" uniqKey="Chan K" first="K S" last="Chan">K S Chan</name></author><author><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K Y" last="Yuen">K Y Yuen</name></author></analytic><series><title level="j">The European respiratory journal</title><idno type="ISSN">0903-1936</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Cohort Studies</term><term>Confidence Intervals</term><term>DNA, Viral (analysis)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Probability</term><term>Prognosis</term><term>Retrospective Studies</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Risk Assessment</term><term>SARS Virus (isolation & purification)</term><term>Sensitivity and Specificity</term><term>Severe Acute Respiratory Syndrome (diagnosis)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Severity of Illness Index</term><term>Time Factors</term><term>Viral Load</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral (analyse)</term><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Charge virale</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Intervalles de confiance</term><term>Mâle</term><term>Probabilité</term><term>Pronostic</term><term>RT-PCR</term><term>Sensibilité et spécificité</term><term>Syndrome respiratoire aigu sévère (diagnostic)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS (isolement et purification)</term><term>Études de cohortes</term><term>Études rétrospectives</term><term>Évaluation des risques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>DNA, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ADN viral</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Cohort Studies</term><term>Confidence Intervals</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Probability</term><term>Prognosis</term><term>Retrospective Studies</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Risk Assessment</term><term>Sensitivity and Specificity</term><term>Severity of Illness Index</term><term>Time Factors</term><term>Viral Load</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Charge virale</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Intervalles de confiance</term><term>Mâle</term><term>Probabilité</term><term>Pronostic</term><term>RT-PCR</term><term>Sensibilité et spécificité</term><term>Études de cohortes</term><term>Études rétrospectives</term><term>Évaluation des risques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a highly infectious respiratory infection with a high mortality. The duration of infectivity is unknown. The RT-PCR positivity for SARS-associated coronavirus (SARS-CoV) was followed in 45 virologically confirmed SARS patients. Serial RT-PCRs for SARS-CoV were performed in the nasopharyngeal aspirate, stool and urine of 45 SARS patients who survived until discharge. All patients had at least one site that was positive for SARS-CoV on presentation. Time to RT-PCR conversion was studied in all patients. There were 15 males (33.3%) and 30 females (66.7%), with a mean+/- SD age of 40.7+/-14.7 yrs. The median (range) time of RT-PCR conversion was 30 days (2-81). On discharge from the hospital, 18 (40%) remained RT-PCR positive in at least one site. For patients with positive RT-PCR on discharge, the median (range) time to RT-PCR conversion after discharge was 13 days (2-60). A significant proportion of severe acute respiratory syndrome patients remained RT-PCR positive for severe acute respiratory syndrome-associated coronavirus for a substantial duration after discharge. The clinical significance is unknown and this finding merits further study. It is prudent to advise patients to adhere to strict personal hygiene on discharge until RT-PCR becomes negative.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Chan, K H" sort="Chan, K H" uniqKey="Chan K" first="K H" last="Chan">K H Chan</name><name sortKey="Chan, K S" sort="Chan, K S" uniqKey="Chan K" first="K S" last="Chan">K S Chan</name><name sortKey="Chan, V L" sort="Chan, V L" uniqKey="Chan V" first="V L" last="Chan">V L Chan</name><name sortKey="Cheng, V C C" sort="Cheng, V C C" uniqKey="Cheng V" first="V C C" last="Cheng">V C C. Cheng</name><name sortKey="Lam, J Y M" sort="Lam, J Y M" uniqKey="Lam J" first="J Y M" last="Lam">J Y M. Lam</name><name sortKey="Leung, W S" sort="Leung, W S" uniqKey="Leung W" first="W S" last="Leung">W S Leung</name><name sortKey="Lin, A W N" sort="Lin, A W N" uniqKey="Lin A" first="A W N" last="Lin">A W N. Lin</name><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K Y" last="Yuen">K Y Yuen</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Chu, C M" sort="Chu, C M" uniqKey="Chu C" first="C M" last="Chu">C M Chu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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